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1

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

Saez-Rodriguez, Julio, Alexopoulos, Leonidas G, Epperlein, Jonathan, Samaga, Regina, Lauffenburger, Douglas A, Klamt, Steffen, Sorger, Peter K

Journal:

Molecular Systems Biology

Year:

2009

Language:

english

File:

PDF, 1.83 MB

english, 2009

2

A systems biology pipeline identifies regulatory networks for stem cell engineering

Kinney, Melissa A., Vo, Linda T., Frame, Jenna M., Barragan, Jessica, Conway, Ashlee J., Li, Shuai, Wong, Kwok-Kin, Collins, James J., Cahan, Patrick, North, Trista E., Lauffenburger, Douglas A., Dale

Journal:

Nature Biotechnology

Year:

2019

Language:

english

File:

PDF, 4.29 MB

english, 2019

3

Measurement of bacterial random motility and chemotaxis coefficients: II. Application of single-cell-based mathematical model

Roseanne M. Ford, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

1991

Language:

english

File:

PDF, 1.07 MB

english, 1991

4

Effects of leukocyte random motility and chemotaxis in tissue inflammatory response

Douglas Lauffenburger, Kenneth H. Keller

Journal:

Journal of Theoretical Biology

Year:

1979

Language:

english

File:

PDF, 1.38 MB

english, 1979

5

Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis

Cynthia L. Stokes, Douglas A. Lauffenburger

Journal:

Journal of Theoretical Biology

Year:

1991

Language:

english

File:

PDF, 1.97 MB

english, 1991

6

Left-Handed Helical Ribbon Intermediates in the Self-Assembly of a β-Sheet Peptide

Marini, Davide M., Hwang, Wonmuk, Lauffenburger, Douglas A., Zhang, Shuguang, Kamm, Roger D.

Journal:

Year:

2002

Language:

english

File:

PDF, 394 KB

english, 2002

7

Molecular properties in cell adhesion: a physical and engineering perspective

Chase E. Orsello, Douglas A. Lauffenburger, Daniel A. Hammer

Journal:

Trends in Biotechnology

Year:

2001

Language:

english

File:

PDF, 95 KB

english, 2001

8

Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis

Chen, Chia-Hung, Miller, Miles A., Sarkar, Aniruddh, Beste, Michael T., Isaacson, Keith B., Lauffenburger, Douglas A., Griffith, Linda G., Han, Jongyoon

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

9

Self-Assembly of a β-Sheet Protein Governed by Relief of Electrostatic Repulsion Relative to van der Waals Attraction

Caplan, Michael R., Moore, Peter N., Zhang, Shuguang, Kamm, Roger D., Lauffenburger, Douglas A.

Journal:

Biomacromolecules

Year:

2000

Language:

english

File:

PDF, 94 KB

english, 2000

10

Logic-Based Models for the Analysis of Cell Signaling Networks

Morris, Melody K., Saez-Rodriguez, Julio, Sorger, Peter K., Lauffenburger, Douglas A.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.95 MB

english, 2010

11

Mathematical Aspects of Microbial Ecology || Editorial

Frank Hoppensteadt, Douglas A. Lauffenburger and Paul Waltman

Journal:

Microbial Ecology

Year:

1991

Language:

english

File:

PDF, 98 KB

english, 1991

12

Mathematical Aspects of Microbial Ecology || Stopped-Flow Chamber and Image Analysis System for Quantitative Characterization of Bacterial Population Migration: Motility and Chemotaxis of Escherichia coli K12 to Fucose

Roseanne M. Ford, Bret R. Phillips, John A. Quinn and Douglas A. Lauffenburger

Journal:

Microbial Ecology

Year:

1991

Language:

english

File:

PDF, 567 KB

english, 1991

13

Mathematical Aspects of Microbial Ecology || Quantitative Studies of Bacterial Chemotaxis and Microbial Population Dynamics

Douglas A. Lauffenburger

Journal:

Microbial Ecology

Year:

1991

Language:

english

File:

PDF, 331 KB

english, 1991

14

High-Affinity CD25-Binding IL-2 Mutants Potently Stimulate Persistent T Cell Growth †

Rao, Balaji M., Driver, Ian, Lauffenburger, Douglas A., Wittrup, K. Dane

Journal:

Year:

2005

Language:

english

File:

PDF, 103 KB

english, 2005

15

Reproducible Automated Phosphopeptide Enrichment Using Magnetic TiO 2 and Ti-IMAC

Tape, Christopher J., Worboys, Jonathan D., Sinclair, John, Gourlay, Robert, Vogt, Janis, McMahon, Kelly M., Trost, Matthias, Lauffenburger, Douglas A., Lamont, Douglas J., Jørgensen, Claus

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

16

Nature's Complex Copolymers: Engineering Design of Oligopeptide Materials

Caplan, Michael R., Lauffenburger, Douglas A.

Journal:

Industrial & Engineering Chemistry Research

Year:

2002

Language:

english

File:

PDF, 289 KB

english, 2002

17

Interstitial Fluid Flow Intensity Modulates Endothelial Sprouting in Restricted Src-Activated Cell Clusters During Capillary Morphogenesis

Hernández Vera, Rodrigo, Genové, Elsa, Alvarez, Lery, Borrós, Salvador, Kamm, Roger, Lauffenburger, Douglas, Semino, Carlos E.

Journal:

Tissue Engineering Part A

Year:

2009

Language:

english

File:

PDF, 30.87 MB

english, 2009

18

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Jamie B. Spangler, Jason R. Neil, Sivan Abramovitch, Yosef Yarden, Forest M. White, Douglas A. Lauffenburger, K. Dane Wittrup and John Kuriyan

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

19

Modeling Tumor Clonal Evolution for Drug Combinations Design

Zhao, Boyang, Hemann, Michael T., Lauffenburger, Douglas A.

Journal:

Trends in Cancer

Year:

2016

Language:

english

File:

PDF, 2.36 MB

english, 2016

20

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Tape, Christopher J., Ling, Stephanie, Dimitriadi, Maria, McMahon, Kelly M., Worboys, Jonathan D., Leong, Hui Sun, Norrie, Ida C., Miller, Crispin J., Poulogiannis, George, Lauffenburger, Douglas A.,

Journal:

Year:

2016

Language:

english

File:

PDF, 56 KB

english, 2016

21

SPIE Proceedings [SPIE SPIE Defense, Security, and Sensing - Orlando, Florida, United States (Monday 25 April 2011)] Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering IX - Cellular defense processes regulated by pathogen-elicited receptor signaling

Wu, Rongcong, Szu, Harold, Goldsipe, Arthur, Schauer, David B., Lauffenburger, Douglas A.

Year:

2011

Language:

english

File:

PDF, 7.26 MB

english, 2011

22

Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments: Figure 1

Clarke, David C., Lauffenburger, Douglas A.

Journal:

Biochemical Society Transactions

Year:

2012

Language:

english

File:

PDF, 352 KB

english, 2012

23

ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker

Yoneyama, Toshie, Gorry, Michael, Sobo-Vujanovic, Andrea, Lin, Yan, Vujanovic, Lazar, Gaither-Davis, Autumn, Moss, Marcia L., Miller, Miles A, Griffith, Linda G., Lauffenburger, Douglas A., Stabile, L

Journal:

Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 1023 KB

english, 2018

24

Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates

Yoneyama, Toshie, Gorry, Michael, Miller, Miles A, Gaither-Davis, Autumn, Lin, Yan, Moss, Marcia L., Griffith, Linda G., Lauffenburger, Douglas A., Stabile, Laura P., Herman, James G., Vujanovic, Niko

Journal:

Journal of Cancer

Year:

2017

Language:

english

File:

PDF, 2.73 MB

english, 2017

25

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

Rohani, Nazanin, Hao, Liangliang, Alexis, Maria S, Joughin, Brian A, Krismer, Konstantin, Moufarrej, Mira N, Soltis, Anthony R, Lauffenburger, Douglas A., Yaffe, Michael B., Burge, Christopher B, Bhat

Journal:

Cancer Research

Year:

2019

Language:

english

File:

PDF, 13.26 MB

english, 2019

26

In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

Luthria, Gaurav, Li, Ran, Wang, Stephanie, Prytyskach, Mark, Kohler, Rainer H., Lauffenburger, Douglas A., Mitchison, Timothy J., Weissleder, Ralph, Miller, Miles A.

Journal:

Nature Communications

Year:

2020

File:

PDF, 5.80 MB

2020

27

Deconstructing (and reconstructing) cell migration

Maheshwari, Gargi, Lauffenburger, Douglas A.

Journal:

Microscopy Research and Technique

Year:

1998

Language:

english

File:

PDF, 162 KB

english, 1998

28

Shaping up for shipping out: PLCγ signaling of morphology changes in EGF-stimulated fibroblast migration

Alan Wells, Margaret F. Ware, Fred D. Allen, Douglas A. Lauffenburger

Journal:

Year:

1999

Language:

english

File:

PDF, 114 KB

english, 1999

29

Intracellular receptor/ligand sorting based on endosomal retention components

Anthony R. French, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

1996

Language:

english

File:

PDF, 1.62 MB

english, 1996

30

Engineering dynamics of growth factors and other therapeutic ligands

Douglas A. Lauffenburger, Lily Chu, Anthony French, Gregory Oehrtman, Cartikeya Reddy, Alan Wells, Salil Niyogi, H. Steven Wiley

Journal:

Biotechnology and Bioengineering

Year:

1996

File:

PDF, 1.28 MB

1996

31

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

David V. Schaffer, Nick A. Fidelman, Nily Dan, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 1.06 MB

english, 2000

32

Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor α

Cartikeya C. Reddy, Alan Wells, Douglas A. Lauffenburger

Journal:

Journal of Cellular Physiology

Year:

1996

Language:

english

File:

PDF, 639 KB

english, 1996

33

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions

Jason M. Haugh, Alan Wells, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 592 KB

english, 2000

34

Receptor-mediated targeting of gene delivery vectors: Insights from molecular mechanisms for improved vehicle design

Csanad M. Varga, Thomas J. Wickham, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 216 KB

english, 2000

35

Cell transport in the millipore filter assay

Helen M. Buettner, Douglas A. Lauffenburger, Sally H. Zigmond

Journal:

Year:

1989

Language:

english

File:

PDF, 746 KB

english, 1989

36

Measurement of individual cell migration parameters for human tissue cells

Paul A. DiMilla, John A. Quinn, Steven M. Albelda, Douglas A. Lauffenburger

Journal:

Year:

1992

Language:

english

File:

PDF, 1.41 MB

english, 1992

37

Physical forces and the mammalian cell. Edited by J. A. Frangos, Academic Press, 1993, 400 pp.

Douglas A. Lauffenburger

Journal:

Year:

1994

Language:

english

File:

PDF, 263 KB

english, 1994

38

Model for ER chaperone dynamics and secretory protein interactions

Anne Skaja Robinson, Douglas A. Lauffenburger

Journal:

Year:

1996

Language:

english

File:

PDF, 1.28 MB

english, 1996

39

Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis

Sowmya Viswanathan, Tania Benatar, Maria Mileikovsky, Douglas A. Lauffenburger, Andras Nagy, Peter W. Zandstra

Journal:

Biotechnology and Bioengineering

Year:

2003

Language:

english

File:

PDF, 278 KB

english, 2003

40

Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix

Wendy A. Prudhomme, Keith H. Duggar, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

2004

Language:

english

File:

PDF, 971 KB

english, 2004

41

Quantitative methods for developing Fc mutants with extended half-lives

Daniel T. Kamei, Bert J. Lao, Margaret Speed Ricci, Rohini Deshpande, Han Xu, Bruce Tidor, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

2005

Language:

english

File:

PDF, 355 KB

english, 2005

42

Marrow-Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

Shelly R. Peyton, Z. Ilke Kalcioglu, Joshua C. Cohen, Anne P. Runkle, Krystyn J. Van Vliet, Douglas A. Lauffenburger, Linda G. Griffith

Journal:

Biotechnology and Bioengineering

Year:

2011

Language:

english

File:

PDF, 728 KB

english, 2011

43

Quantification of bacterial chemotaxis by measurement of model parameters using the capillary assay

Mercedes Rivero-Hudec, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

1986

Language:

english

File:

PDF, 963 KB

english, 1986

44

Measurement of bacterial random motility and chemotaxis coefficients: I. Stopped-flow diffusion chamber assay

Roseanne M. Ford, Bret R. Phillips, John A. Quinn, Douglas A. Lauffenburger

Journal:

Biotechnology and Bioengineering

Year:

1991

Language:

english

File:

PDF, 1.28 MB

english, 1991

45

Quantitative relationships between single-cell and cell-population model parameters for chemosensory migration responses of alveolar macrophages to C5a

Brian E. Farrell, Ronald P. Daniele, Douglas A. Lauffenburger

Journal:

Year:

1990

Language:

english

File:

PDF, 1.40 MB

english, 1990

46

An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-α

Benjamin D. Cosgrove, Connie Cheng, Justin R. Pritchard, Donna B. Stolz, Douglas A. Lauffenburger, Linda G. Griffith

Journal:

Year:

2008

Language:

english

File:

PDF, 2.12 MB

english, 2008

47

pH Sensitivity of epidermal growth factor receptor complexes

Marissa Nunez, Kevin H. Mayo, Cindy Starbuck, Douglas Lauffenburger

Journal:

Journal of Cellular Biochemistry

Year:

1993

Language:

english

File:

PDF, 827 KB

english, 1993

48

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

Manu O. Platt, Arian J. Roman, Alan Wells, Douglas A. Lauffenburger, Linda G. Griffith

Journal:

Journal of Cellular Physiology

Year:

2009

Language:

english

File:

PDF, 694 KB

english, 2009

49

A Rapid and Sensitive Quantitative Kinase Activity Assay Using a Convenient 96-Well Format

Anand R. Asthagiri, Alan F. Horwitz, Douglas A. Lauffenburger

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 119 KB

english, 1999

50

Analysis of Receptor Internalization as a Mechanism for Modulating Signal Transduction

Jason M. Haugh, Douglas A. Lauffenburger

Journal:

Journal of Theoretical Biology

Year:

1998

Language:

english

File:

PDF, 575 KB

english, 1998